Effect of sinomenine on adjuvant arthritis and its mechanisms / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1361-1363, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-239682
ABSTRACT
<p><b>OBJECTIVE</b>To discuss the anti-inflammatory mechanism of sinomenine on inflammatory media in joint of adjuvant arthritis rats.</p><p><b>METHOD</b>Rats were randomly divided into the normal group and the model group, the prednisone group, the small, medium, large of sinomenine group (30, 60, 120 mg x kg(-1)). Except for the rats in the normal group, animals were modeled to adjuvant arthritiswith freund's complete adjuvant. The arthritis index (AI) and the swelling degree of paws were recorded, and the activity of IL-1, TNF and the levels of NO, PGE2 in joint fluids of secondary arthritis were determined.</p><p><b>RESULT</b>Compared with the normal group, the activity of IL-1, TNF and the levels of NO, PGE2 in joint fluids of secondary arthritis were increased significantly in the model group (P < 0.05). Compared with the model group, it was shown to exert a dramatic inhibitory effect on secondary reaction of freund's adjuvant arthritis of rats, and the activity of IL-1, TNF and the levels of NO, PGE2 in joint fluids of secondary arthritis were significantly decreased in the sinomenine group (P < 0.05).</p><p><b>CONCLUSION</b>Sinomenine has a remarkable treatment effect on RA. It is via NO to inhibit the activity of cytokines and decrease the level of inflammation mediators, which may be one of its curing RA mechanism.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Artritis Experimental
/
Líquido Sinovial
/
Medicamentos Herbarios Chinos
/
Dinoprostona
/
Distribución Aleatoria
/
Química
/
Antiinflamatorios no Esteroideos
/
Interleucina-1
/
Ratas Wistar
/
Sinomenium
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2005
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS