Solubilization on cryptotanshinone by hydroxypropyl-beta-cyclodextrin and preparation of their inclusion compound / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To prepare cryptotanshinone (CT)-cyclodextrin inclusion compound and improve dissolution of CT.</p><p><b>METHOD</b>Inclusion ratio was determined by plotting the phase solubility curve of CT versus hydroxypropyl-beta-cyclodextrin (HPCD). CT-cyclodextrin inclusion compound was made by wet grinding method. Properties of the inclusion compound was investigated by in vitro dissolution test, DTA and IR spectrum.</p><p><b>RESULT</b>Inclusion ratio of CT versus HPCD was 11. Dissolution of CT-HPCD inclusion compound at 45 min was 21.6 times of material drug.</p><p><b>CONCLUSION</b>Dissolution of CT was improved remarkably in CT-HPCD inclusion compound. The complexation force of the inclusion compound was hydrogen bond formed by carbonyl group of CT and hydroxyl group of HPCD.</p>