Effects of xianggui pill on cytokine in endometriosis model rat / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the adjustment of Xianggui pill on the cytokine of endometriosis model rat, and investigate the mechanism of Xianggui pill on the treatment of endometriosis.</p><p><b>METHOD</b>To set up endometriosis model by rat self-endometria transplantation, drench sodium chloride, Xianggui pill elixation or Danazol after grouping, and to detect the contents of interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha) by ELISA.</p><p><b>RESULT</b>The contents of IL-8, TNF-alpha in the peripheral blood and peritoneal fluid of model group were higher than that of the blank group; The quality of allotopia growth intima tissue, the quantity of macrophage in peritoneal fluid and the contents of IL-8, TNF-alpha in the Xianggui pill group and Danazol group were all lower than those of the model group; but there was no significant difference of each target between the Xianggui pill group and Danazol group.</p><p><b>CONCLUSION</b>Xianggui pill can restrain significantly the growth of allotopia intima tissue, and has apparently adjustment to the cytokine.</p>