Detection of hepatitis E virus on a blood donor and its infectivity to rhesus monkey / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 13-15, 2004.
Artículo
en Chino
| WPRIM
| ID: wpr-240525
ABSTRACT
<p><b>OBJECTIVE</b>To understand the infectivity and pathogenicity of the plasma of hepatitis E virus (HEV) viremia to primate animals.</p><p><b>METHODS</b>RNA fragment of HEV genotype IV was detected on one healthy donor who was positive for anti-HEV IgM and negative for anti-HEV IgG. Then 10 ml plasma from above donor was transfused to rhesus monkey to observe its infectivity and pathogenicity.</p><p><b>RESULTS</b>Acute hepatitis E was developed in rhesus monkey who accept HEV RNA positive plasma. It was confirmed by virological, immunological, biochemical and histopathological data.</p><p><b>CONCLUSION</b>Acute hepatitis E can be induced by plasma transfusion of HEV viremia, which indicate the possibility of transfusion transmitted hepatitis E</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Sangre
/
Donantes de Sangre
/
ARN Viral
/
Enfermedad Aguda
/
Virus de la Hepatitis E
/
Hepatitis E
/
Reacción a la Transfusión
/
Macaca mulatta
Tipo de estudio:
Estudio diagnóstico
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Hepatology
Año:
2004
Tipo del documento:
Artículo
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