Establishment of analogous oxidative damaged Alzheimer's disease rat model and effect of tiaoxin recipe on it / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 603-605, 2003.
Artículo
en Chino
| WPRIM
| ID: wpr-240910
ABSTRACT
<p><b>OBJECTIVE</b>To establish a convenient, economical and practical analogous oxidative damaged Alzheimer's disease rat model (AD model) for exploring the effect of Tiaoxin Recipe (TXR) on the spatial memory capacity and beta-amyloid protein (A beta) deposition in the model.</p><p><b>METHODS</b>The AD model was established by left ventricular injection of DHF-FeCl3-ADP. Spatial memory and learning capacity of the model rat was observed by Morris water maze method, A beta deposition in its cerebral cortex was observed by immunohistochemistry, and the effect of TXR was analysed.</p><p><b>RESULTS</b>Compared with the normal group, the spatial memory capacity in the model group was obviously decreased, with A beta widely deposited in cortex, immunohistochemical examination showed that the number of A beta positive cells and their mean optic density significantly increased. TXR displayed significantly improving effect on the above-mentioned changes.</p><p><b>CONCLUSION</b>The oxidative damaged model could not only express the clinical characteristics (short-term memory impairment), but also partially reflex the pathological changes (A beta deposition) of AD, is an economical and practical analogous AD model. TXR has the effects of improving spatial memory impairment and lowering A beta deposition in the AD model rats.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Medicamentos Herbarios Chinos
/
Corteza Cerebral
/
Péptidos beta-Amiloides
/
Especies Reactivas de Oxígeno
/
Ratas Sprague-Dawley
/
Usos Terapéuticos
/
Modelos Animales de Enfermedad
/
Quimioterapia
/
Enfermedad de Alzheimer
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Chino
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Año:
2003
Tipo del documento:
Artículo
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