Experimental varicocele affects VEGF and Flt-1 protein expressions in the testis and epididymis of adolescent rats / 中华男科学杂志
National Journal of Andrology
;
(12): 488-492, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-241314
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of experimental left varicocele (ELV) on the vascular endothelial growth factor (VEGF) and its receptor fms-like tyrosine kinase-1 (Flt-1) proteins in the testis and epididymis of adolescent rats, and to find out the correlation of the two proteins with varicocele-induced male infertility.</p><p><b>METHODS</b>We established the ELV model in adolescent male SD rats, and detected the expressions of VEGF and Flt-1 proteins in the testis and epididymis by immunohistochemistry at 2 and 4 weeks after surgery.</p><p><b>RESULTS</b>Cell- and region-specific expressions of VEGF and Flt-1 were observed in the testis and epididymis of the ELV and control groups. Statistical analysis showed that, in comparison with the corresponding control groups, the 2- and 4-week ELV groups exhibited a notable increase in the VEGF protein expression in the hibateral testis and epididymis (P < 0.01, P < 0.05); the Flt-1 expression was obviously upregulated in the hibateral testis and epididymis of the 2-week ELV group (P < 0.01, P < 0.01), but remarkably reduced in the hibateral testis and left epididymis of the 4-week ELV group (P < 0.01, P < 0.05), with no statistic difference in the right epididymis (P > 0.05).</p><p><b>CONCLUSION</b>ELV can cause changes in the expressions of VEGF and Flt-1 proteins in the testis and epididymis of adolescent rats, and consequently affect spermatogenesis and spermiotelcosis, which may be one of the causes of varicocele-induced male infertility or subfertility.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Testículo
/
Varicocele
/
Expresión Génica
/
Ratas Sprague-Dawley
/
Receptor 1 de Factores de Crecimiento Endotelial Vascular
/
Factor A de Crecimiento Endotelial Vascular
/
Modelos Animales de Enfermedad
/
Epidídimo
/
Metabolismo
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Chino
Revista:
National Journal of Andrology
Año:
2009
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS