Invasive ductal carcinomas of breast showing partial reversed cell polarity are associated with lymphatic tumor spread / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 305-308, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-241925
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between partial reversed cell polarity (PRCP) and lymphatic tumor spread in invasive ductal carcinoma (IDC), not othervise specified (NOS).</p><p><b>METHODS</b>Immunohistochemistry (EnVision method) was used to examine the expression of epithelial membrane antigen (EMA) and the reversed cell polarity in 199 cases of IDC.</p><p><b>RESULTS</b>Of the 199 cases, including five cases with micropapillary differentiation,30 cases with PRCP and 164 cases of IDC-NOS (without micropapillary differentiation and/or PRCP), lymphovascular invasion was seen in four (4/5), 13(43.3%) and 30 cases (18.3%) respectively; nodal metastasis was seen in four (4/5), 19 (63.3%) and 56 cases (34.1%) respectively. The rates of lymphovascular invasion and nodal metastasis were significantly higher in IDC with PRCP or IMPC than IDC-NOS (P = 0.00); there was however no significant difference between IDC with PRCP and IMPC for lymphovascular invasion and nodal metastasis (P = 0.18, P = 0.64).</p><p><b>CONCLUSIONS</b>IDC with PRCP, similar to IMPC, is more likely to show lymphovascular invasion and nodal metastasis. Complete or partial reversal of cell polarity may play a significant role in lymphatic tumor spread.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Neoplasias de la Mama
/
Inmunohistoquímica
/
Carcinoma Papilar
/
Polaridad Celular
/
Carcinoma Ductal de Mama
/
Mucina-1
/
Metástasis Linfática
/
Metabolismo
/
Invasividad Neoplásica
Límite:
Femenino
/
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Pathology
Año:
2012
Tipo del documento:
Artículo
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