Clinical significance of TET2 gene expression in 157 adult acute myeloid leukemia patients with normal cytogenetics / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 802-807, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-242055
ABSTRACT
<p><b>OBJECTIVE</b>To explore the clinical significance of ten-eleven-translocation methylcytosine dioxygenase 2 (TET2) mRNA expression levels in adult acute myeloid leukemia patients with normal cytogenetics (CN-AML).</p><p><b>METHODS</b>Expression levels of TET2 mRNA were measured by real-time PCR in 157 adult CN-AML, and its clinical impact in CN-AML was evaluated as well.</p><p><b>RESULTS</b>TET2 gene expression levels from bone marrow mononuclear cells (BMMNCs) [7.29(3.41-9.99)] and CD34+ cells [6.02(5.64-6.54)] in CN-AML were significantly lower than those [BMMNCs 8.13(6.68-9.04), P=0.026; CD34+ cells 6.48(5.97-7.12), P=0.034] in healthy control. And TET2 mRNA level at diagnosis [7.32(6.11-8.41)] was obviously lower than that at complete remission [8.39(7.76-8.79), P<0.01]. CN-AML patients with lower levels of TET2 mRNA showed worse survival rate [(32.7±5.9)%] at 18-month than those with higher levels [(48.6±6.9)%, P=0.041]. In multivariate analysis, lower level of TET2 mRNA was an independent prognostic factor for OS [hazard ratio(HR)2.032, 95% confidence interval (CI)1.272-3.247, P=0.003] and event-free survival [HR 1.532, 95% CI 1.014-2.314, P=0.043].</p><p><b>CONCLUSION</b>The level of TET2 mRNA is significantly lower in patients with CN-AML and it is an independent negative prognostic factor. TET2 could be an important factor for the molecular-based risk stratification in CN-AML.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Leucemia Mieloide Aguda
/
Expresión Génica
/
Regulación Neoplásica de la Expresión Génica
/
Proteínas Proto-Oncogénicas
/
Supervivencia sin Enfermedad
/
Análisis Citogenético
/
Perfilación de la Expresión Génica
/
Citogenética
/
Proteínas de Unión al ADN
/
Reacción en Cadena en Tiempo Real de la Polimerasa
Tipo de estudio:
Estudio pronóstico
Límite:
Adulto
/
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Hematology
Año:
2014
Tipo del documento:
Artículo
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