Chronic lymphocytic leukemia with central nervous system invasion: one case report and literature review / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 592-595, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-242109
ABSTRACT
<p><b>OBJECTIVE</b>To investigate clinical features, diagnosis, therapy, and prognosis in a case of chronic lymphocytic leukemia (CLL) with central nervous system (CNS) invasion.</p><p><b>METHODS</b>The cellular morphology of bone marrow, cytology and flow cytometry of cells in CSF, and radiographic manifestations were detected in a patient diagnosed as CLL with CNS invasion. The clinical features, pathogenesis, diagnosis,therapy, and prognosis of CLL with CNS invasion were reviewed by literatures.</p><p><b>RESULTS</b>A clonal population of B lymphocytes with typical characteristics of immunophenotype was identified in the patient. After treated with intrathecal chemotherapy, the patient returned to normal cells count of cerebrospinal fluid and normal neurologic status. Previous studies also have demonstrated the efficacy of intrathecal chemotherapy.</p><p><b>CONCLUSION</b>CNS invasion is a rare complication of CLL. Early detection and treatment may result in better outcomes.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Pronóstico
/
Leucemia Linfocítica Crónica de Células B
/
Sistema Nervioso Central
/
Infiltración Leucémica
Tipo de estudio:
Estudio pronóstico
/
Estudio de tamizaje
Límite:
Anciano
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Hematology
Año:
2014
Tipo del documento:
Artículo
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