A clinicopathological study of Castleman's disease / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 521-524, 2003.
Artículo
en Chino
| WPRIM
| ID: wpr-242147
ABSTRACT
<p><b>OBJECTIVE</b>To study the pathogenesis and the differential diagnosis of Castleman's disease.</p><p><b>METHODS</b>Histopathology, immunohistochemical staining and clinical courses of 26 cases of Castleman's disease (CD) were studied with follow-up study of 16 cases.</p><p><b>RESULTS</b>The present study included 6 cases of multicentric type, 20 cases of localized type in the clinical aspects and 19 cases with hyaline vascular type, 4 cases with plasma cell type, 3 cases with mixed type in the histologic aspect. The Multicentric type presented systemic lymphadenopathy, anemia, hyperglobulinemia, hepatosplenomegaly, skin changes, and lung disorder and kidney disfunction, of which 1 case died of respiratory and renal insufficiency. 13 of the 20 localized cases were of the hyaline vascular type, and with good prognosis. 7 of the 20 cases showed paraneoplastic pemphigus associated with hyperglobulinemia (4/7) and lung disease (5/7). The pathologic features composed of proliferation of the mantle zone B cell, follicular dendritic cell, plasma cell and small vessels. In immunohistochemical staining, kappa and lambda light chains were detected in each CD case.</p><p><b>CONCLUSIONS</b>Many diseases are similar to CD clinicopathologically. It is important to make differential diagnosis through pathological study. Castleman's disease is a lymphoproliferative disorder. The pathogenesis of this multicentric disorder may be associated with autoimmune disease.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Cirugía General
/
Inmunohistoquímica
/
Estudios de Seguimiento
/
Enfermedad de Castleman
/
Pénfigo
/
Resultado del Tratamiento
/
Antígenos Comunes de Leucocito
/
Antígenos CD20
/
Diagnóstico Diferencial
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio diagnóstico
/
Estudio observacional
/
Estudio pronóstico
Límite:
Adolescente
/
Adulto
/
Anciano
/
Niño
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Pathology
Año:
2003
Tipo del documento:
Artículo
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