Effect of ginseng-sanqi extract on the Ras associated signal proteins / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 802-805, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-242393
ABSTRACT
<p><b>OBJECTIVE</b>To explore the effect of ginseng-sanqi extract (GSE) on the vascular endothelium growth factor receptor-2 (VEGFR-2), Ras and mitogen-activated protein kinase (MAPK) in VEGFR-2-Ras-MAPK signal pathway of angiogenesis in cultured human umbilical vascular endothelial cells (HUVECs).</p><p><b>METHODS</b>The protein expressions of VEGFR-2, Ras and MAPK in HUVEC and the effects of GSE (at different doses) and basic fibrin growth factor (bFGF) on them were detected by Western-Blot test.</p><p><b>RESULTS</b>GSE can enhance the expression of angiogenesis signaling proteins (VEGFR-2, Ras, MAPK) to different extents, especially in the groups treated by bFGF or higher dose GSE, the levels showed significant differences to those in the blank group (P<0.05).</p><p><b>CONCLUSION</b>GSE can promote the expressions of VEGFR-2, Ras and MAPK in the angiogenesis signaling pathway, which may be the foundation of Chinese medicine for tonifying qi and activating blood circulation in promoting endothelial proliferation and angiogenesis.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Medicamentos Herbarios Chinos
/
Transducción de Señal
/
Células Cultivadas
/
Proteínas Quinasas Activadas por Mitógenos
/
Ginsenósidos
/
Receptor 2 de Factores de Crecimiento Endotelial Vascular
/
Células Endoteliales de la Vena Umbilical Humana
/
Metabolismo
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Año:
2009
Tipo del documento:
Artículo
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