The Gingival Tissue Levels of Bone Resorptive Mediators in Human Chronic Periodontitis with Type 2 Diabetes Mellitus / 대한치주과학회지
The Journal of the Korean Academy of Periodontology
; : 743-753, 2007.
Article
en Ko
| WPRIM
| ID: wpr-24279
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE: The purposes of this study were to compare and quantify the expression of MMP-3, PGE2 and IL-6 in the gingival tissues of patients with type2 diabetes mellitus and healthy adults with chronic periodontitis. MATERIAL AND METHODS: Gingival tissue samples were obtained during periodontal surgery or tooth extraction. According to the patient's systemic condition & clinical criteria of gingiva, each gingival sample was devided into three groups. Group 1(n=8) is clinically healthy gingiva without bleeding and no evidence of bone resorption or periodontal pockets, obtained from systemically healthy 8 patients. Group 2(n=8) is inflamed gingiva from patients with chronic periodontitis. Group 3(n=8) is inflamed gingiva from patients with chronic periodontitis associated with type 2 DM. Tissue samples were prepared and analyzed by Westernblotting. The quantification of MMP-3, PGE2 and IL-6 were performed using a densitometer and statistically analyzed by one-way ANOVA followed by Tukey test. RESULTS: 1. The expression levels of MMP-3 were shown highest in group 3 compared to group 1 and 2, and It showed increasing tendency in group 2 and 3. 2. The expressions of PGE2 and IL-6 were shown increasing tendency in group 2 and 3, and It was highest in group 3. 3. As expressions of MMP-3 were increased, PGE2 and IL-6 expressions showed increasing tendency in group 3 than group1 and 2, although there were no proportional relationship. CONCLUSION: This study demonstrated that the expression levels of MMP-3, PGE2 and IL-6 will be inflammatory markers of periodonta linflamed tissue and DM. It can be assumed that MMP-3 affect to expressions of PGE2 and IL-6 in progression of periodontal inflammation with alveolar bone resorption to type 2 DM.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Bolsa Periodontal
/
Extracción Dental
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Resorción Ósea
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Dinoprostona
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Interleucina-6
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Diabetes Mellitus
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Diabetes Mellitus Tipo 2
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Periodontitis Crónica
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Encía
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Hemorragia
Límite:
Adult
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Humans
Idioma:
Ko
Revista:
The Journal of the Korean Academy of Periodontology
Año:
2007
Tipo del documento:
Article