Progress of targeting transforming growth factor-β1 small interfering RNA in liver fibrosis / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal
;
(4): 231-235, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-242863
ABSTRACT
Liver fibrosis is a common pathological consequence of a variety of chronic stimuli, including viral, autoimmune, drug-induced, cholestatic and metabolic diseases. Fibrosis is driven by a dynamic process involving increased synthesis of matrix components and a failure of physiological mechanisms of matrix turnover. Activation of hepatic stellate cells (HSCs) remains a central event in fibrosis. HSCs are the main source of extracellular matrix (ECM). Transforming growth factor-beta (TGF-Β), which is the fibrogenic master cytokine, can induce the activation of HSCs to produce a large amount of ECM, and is capable of inducing apoptosis of liver cells. RNA interference (RNAi) is a novel gene disruption technology. Studies have shown that small interfering RNA (siRNA) targeting TGF-Β1 may inhibit the activation and proliferation of HSCs, suppress ECM synthesis and block liver fibrosis. TGF-Β1 siRNA-mediated gene silencing therapy provides a new avenue for liver fibrosis. This review summarizes recent progresses in research on HSCs, TGF-Β1 and TGF-Β1 siRNA in liver fibrosis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Terapéutica
/
ARN Interferente Pequeño
/
Factor de Crecimiento Transformador beta1
/
Genética
/
Cirrosis Hepática
Idioma:
Inglés
Revista:
Chinese Medical Sciences Journal
Año:
2014
Tipo del documento:
Artículo
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