Relationship between transforming growth factor beta-1 gene-509C/T polymorphism and severe chronic periodontitis / 中华口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the relationship between transforming growth factor beta-1 (TGF-β(1)) gene-509C/T polymorphism and severe chronic periodontitis in Chinese Hans population.</p><p><b>METHODS</b>TGF-β(1)-509C/T genotype polymorphism was analyzed in 102 patients with severe chronic periodontitis (periodontitis group) and 102 healthy controls (control group) by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method.</p><p><b>RESULTS</b>The distributions of TGF-β(1)-509C/T genotype and allele were significantly different between severe chronic periodontitis group and control group (P < 0.05). TGF-β(1)-509CC, CT and TT genotype frequency were 44.1% (45/102), 47.1% (48/102), 8.8% (9/102) in periodontitis group and 29.4% (30/102), 51.0% (52/102), 19.6% (20/102) in control group, respectively. The relative risk analysis found that C allele carriers had higher risk of suffering from severe chronic periodontitis compared with T allele carriers (OR = 1.718, 95%CI 1.148-2.569).</p><p><b>CONCLUSIONS</b>TGF-β(1)-509C/T polymorphism is associated with severe chronic periodontitis in Chinese Hans population, and C allele may be an important genetic susceptibility gene for severe chronic periodontitis.</p>