Paclitaxel plus carboplatin for women with advanced breast cancer / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal
; (4): 93-97, 2007.
Article
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| WPRIM
| ID: wpr-243550
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and safety of combination chemotherapy with paclitaxel and carboplatin for advanced breast cancer (ABC).</p><p><b>METHODS</b>From January 2001 to March 2006, 45 patients with ABC were treated with combination chemotherapy of paclitaxel and carboplatin. Patients received infusion of paclitaxel 175 mg/m2 on day 1 every 3 weeks or 75 mg/m2 on day 1, 8, 15 every 4 weeks. Carboplatin was administrated on day 2 with a dose of area under the time-concentration curve (AUC) being 5.</p><p><b>RESULTS</b>The median number of cycles was 3 (range, 2-6). The overall response rate was 62.2%. Median time to progression was 7.0 months (95% CI: 5.1-8.9). Median overall survival was 29.0 months (95% CI: 20.1-37.9). One year survival rate was 73.3%. Response rate for first line and second line treatment were 62.1% and 62.5% , respectively. No significant difference in response existed between visceral metastasis and soft tissue metastasis. The main side effects included nausea/vomiting, neurotoxicity, and hematologic toxicities. Grade III to IV adverse events included nausea/vomiting in 2 cases (4.4%), leukopenia in 17 cases (37.8%) , and alopecia in 6 cases (13.3%).</p><p><b>CONCLUSION</b>Combination of paclitaxel and carboplatin is active in treatment of ABC with an acceptable toxicity profile.</p>
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Asunto principal:
Patología
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Neoplasias de los Tejidos Blandos
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Vómitos
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Neoplasias de la Mama
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Esquema de Medicación
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Protocolos de Quimioterapia Combinada Antineoplásica
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Tasa de Supervivencia
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Mortalidad
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Carboplatino
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Paclitaxel
Tipo de estudio:
Prognostic_studies
Límite:
Female
/
Humans
Idioma:
En
Revista:
Chinese Medical Sciences Journal
Año:
2007
Tipo del documento:
Article