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The Combined Effect of Fast Neutron and hyperthermia according to the Sequence and Interval in MKN-45 Cells / 대한방사선종양학회지
The Journal of the Korean Society for Therapeutic Radiology and Oncology ; : 65-69, 1999.
Artículo en Inglés | WPRIM | ID: wpr-24365
ABSTRACT

PURPOSE:

It has been well established that response of cells and tissues to low LET radiations(X- or grmma-ray) can enhanced by comdining with hyperthermia. However, There has been relatively little of hyperthermia on the possible modification of either cellular or tissue responses to other types of radiation. So, We investigated the combined effect of fast neutron irradiation and hyperthermia according to the sequence and time interval of the two MATERIALS AND

METHODS:

In MKN-45 cells, a human stomach cancer cell line, Surviving fractions were measured according to the sequence treatment of 6,4,2,0 hour interval for fast neutron irradiation(1.5Gy) combined with hyperthermia(41 degrees C for 30 min or 43 degrees C for 30 min).

RESULTS:

D(0) and n of MKN-45 for neutron were 0.8Gy and 2.5, respectively. The surviving fraction by 1.5 Gy of neutron was 0.36+/-0.34. Interacting powers were mostly. The surviving fraction by 1.5 Gy of neutron was 0.36+/-0.34. Interacting powers were mostly ranged between 1 and 2, bur they were 3.0Gy 2.7, respectively for hyperthermia (41 degrees C for 30 min) followed by neutron irradiation 6 and 4 hours later.

CONCLUSION:

The combined effect of fast neutron (1.5Gy) and hyperthermia (41 degrees C or 43 degrees C for 30min) is largely independently additive. Preceding mild hyperthermia (41 degrees C for 30 min) 4 or 6 hours before neutron may cause decreased sensitivity to subsequent neutron irradiation.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias Gástricas / Línea Celular / Transferencia Lineal de Energía / Neutrones Rápidos / Fiebre / Neutrones Límite: Humanos Idioma: Inglés Revista: The Journal of the Korean Society for Therapeutic Radiology and Oncology Año: 1999 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias Gástricas / Línea Celular / Transferencia Lineal de Energía / Neutrones Rápidos / Fiebre / Neutrones Límite: Humanos Idioma: Inglés Revista: The Journal of the Korean Society for Therapeutic Radiology and Oncology Año: 1999 Tipo del documento: Artículo