Peripheral dendritic cell subpopulation changes in patients with coronary artery disease / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 209-211, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-243814
ABSTRACT
<p><b>OBJECTIVE</b>To compare the peripheral dendritic cell subpopulation changes in patients with or without coronary artery disease.</p><p><b>METHODS</b>A total of 60 patients with angiographic documented coronary artery disease (CAD) were recruited in this study, including 20 cases with acute myocardial infarction (AMI group), 20 cases with unstable angina(UA group) and 20 patients with stable angina (SA group). Eleven patients with chest pain and without coronary stenosis served as chest pain control (CPS group). Ten cases without heart diseases served as normal control (Normal control group). Numbers of peripheral myeloid dendritic cell (mDC) and plasmacytoid dendritic cell (pDC) precursors were determined by FACS.</p><p><b>RESULT</b>The proportions of mDC precursors were significantly lower in UA group and AMI group (4.7% +/- 2.6%, 5.0% +/- 2.7%) than that in SA, CPS and control groups (11.0% +/- 6.4%, 12.0% +/- 3.9%, 12.3% +/- 3.3%, respectively, all P < 0.001). pDC numbers were similar among groups.</p><p><b>CONCLUSION</b>Reduced circulating mDC subsets in patients with unstable angina and AMI might suggest enhanced mDC recruitment to vulnerable plaques in these patients.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Sangre
/
Enfermedad de la Arteria Coronaria
/
Células Dendríticas
/
Estudios de Casos y Controles
/
Recuento de Células
/
Alergia e Inmunología
/
Angina Inestable
/
Infarto del Miocardio
Tipo de estudio:
Estudio observacional
Límite:
Anciano
/
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Cardiology
Año:
2008
Tipo del documento:
Artículo
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