Clinical implication of microvasculopathy in patients post heart transplantation / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 156-159, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-244033
ABSTRACT
<p><b>OBJECTIVE</b>Assess the clinical implication of microvasculopathy detected by endomyocardial biopsy samples in patients post heart transplantation.</p><p><b>METHODS</b>Light microscopic evaluations were performed in 278 endomyocardial biopsies harvested from 64 patients post heart transplantation for more than one year, microvasculopathy was defined as stenotic endothelial and/or medial disease.</p><p><b>RESULTS</b>The patients with stenotic microvasculopathy were younger than those without microvasculopathy (40.7 ± 15.9 vs. 49.4 ± 8.7, P < 0.05). The mean score of acute cellular rejection (0.83 ± 0.39 vs. 0.37 ± 0.32, P < 0.01) and the numbers of ≥ grade II acute rejection (0.84 ± 0.16 vs. 0.23 ± 0.10, P < 0.01) were significantly greater in stenotic microvasculopathy group compared to those of non-stenotic group. Multivariate regression analysis confirmed that stenotic microvasculopathy is the independent risk factor for the mean acute rejection score (OR = 3.40, 95%CI, 4.62 - 193.07, P < 0.01), but not for the Quilty lesion, coronary heart disease of donor, diabetes mellitus. Angiographically confirmed coronary vasculopathy and cardiac dysfunction (χ(2) = 0.94, P > 0.05 and χ(2) = 2.90, P > 0.05) were similar between microvasculopathy group and non-microvasculopathy group.</p><p><b>CONCLUSION</b>Post heart transplantation microvasculopathy is an immune-mediated phenomenon and associated with higher mean score of acute cellular rejection and higher numbers of ≥ grade II acute rejection but was not the prognostic risk factor for coronary vasculopathy and function reduction after heart transplantation.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Pronóstico
/
Cirugía General
/
Factores de Riesgo
/
Trasplante de Corazón
/
Enfermedad Coronaria
/
Endocardio
/
Oclusión de Injerto Vascular
/
Rechazo de Injerto
/
Miocardio
Tipo de estudio:
Estudio de etiología
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adolescente
/
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Cardiology
Año:
2011
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS