Effects of G894T mutation in the endothelial nitric oxide synthase gene on blood pressure / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 36-39, 2003.
Artículo
en Chino
| WPRIM
| ID: wpr-244233
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the association between G894T (Glu298Asp) mutation at exon 7 in the endothelial nitric oxide synthase gene and essential hypertension.</p><p><b>METHODS</b>One hundred and sixteen essential hypertensives without taking hypertensive medication and 136 normotensives screened from health workers in a steel factory were selected as subjects in this study. Polymerase chain reaction (PCR) and Ban II restriction enzyme digestion were performed to detect the G894T mutation.</p><p><b>RESULTS</b>G894T mutation was significantly associated with essential hypertension. The T allele frequency in essential hypertensive group was significantly higher than that in normotensive group (16.0% versus 8.8%, P = 0.019, OR = 1.96, 95% CI 1.14 - 3.37). The levels of systolic blood pressure and diastolic blood pressure in the G894T mutant genotypes were all significantly elevated in hypertensive, normotensive, and the total subjects (P < 0.05). After adjusting factors as age, sex, smoking, alcohol drinking, body mass index, triglyceride, serum total cholesterol, serum high density lipoprotein cholesterol by analysis of multiple covariance, significant positive effect of the G894T mutant genotypes on blood pressure in the total subjects (P < 0.01) was noticed.</p><p><b>CONCLUSION</b>This study suggested that the G894T mutation in the endothelial nitric oxide synthase gene might serve as a major risk factor of essential hypertension in this study population.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Presión Sanguínea
/
Polimorfismo de Longitud del Fragmento de Restricción
/
China
/
Exones
/
Epidemiología
/
Factores de Riesgo
/
Mutación Puntual
/
Óxido Nítrico Sintasa
/
Predisposición Genética a la Enfermedad
/
Alelos
Tipo de estudio:
Estudio de etiología
/
Factores de riesgo
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
Asia
Idioma:
Chino
Revista:
Chinese Journal of Epidemiology
Año:
2003
Tipo del documento:
Artículo
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