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The prevalence of hepatitis B virus precore mutant isolated from asymptomatic carriers in Guangxi / 中华流行病学杂志
Chinese Journal of Epidemiology ; (12): 453-456, 2002.
Artículo en Chino | WPRIM | ID: wpr-244245
ABSTRACT
<p><b>OBJECTIVE</b>In order to understand the prevalence of hepatitis B virus (HBV) precore mutants isolated from asymtomatic carriers in Guangxi.</p><p><b>METHODS</b>Nested polymerase chain reaction (nPCR) was used for amplification of HBV DNA precore in 77 carrier sera, followed by HBV DNA nPCR products sequencing using direct sequencing.</p><p><b>RESULTS</b>50.7% of 77 carriers was positive for HBV DNA with a prevalence of mutants 22.1% (17/77). HBV DNA positive rate in the southern part of the autonomous region was 55.6% (20/36). Six of them were mutants, counting for 30%. The common mutation in the southern part was seen T-->C at nt1858 while nt1896 stop mutation was discovered in one sample only, which was accompanied by point mutation at nt1837 (A-->G). HBV DNA positive rate in the northern part was 46.3% (19/41) with 11 of them were mutants, counting for 57.9%. The common mutation in that area stopped at nt1896. Among samples with stopped mutation, 4 samples had mutation at nt1846 (A-->T), 2 samples at nt1862 (G-->T). Both mutation at nt1856 (C-->T) and nt1858 (T-->C) could be seen in sample 734.</p><p><b>CONCLUSIONS</b>The prevalence of HBV precore mutant in asymptomatic carriers in Guangxi was at the average level in China. Further study is needed to determine the difference between the southern and the northern part of the region in the common type of mutation exists.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Virología / ADN Viral / Datos de Secuencia Molecular / Secuencia de Bases / Portador Sano / Química / Virus de la Hepatitis B / Reacción en Cadena de la Polimerasa / Genética / Mutación Tipo de estudio: Estudio de prevalencia Límite: Humanos Idioma: Chino Revista: Chinese Journal of Epidemiology Año: 2002 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Virología / ADN Viral / Datos de Secuencia Molecular / Secuencia de Bases / Portador Sano / Química / Virus de la Hepatitis B / Reacción en Cadena de la Polimerasa / Genética / Mutación Tipo de estudio: Estudio de prevalencia Límite: Humanos Idioma: Chino Revista: Chinese Journal of Epidemiology Año: 2002 Tipo del documento: Artículo