Epigenetics and cancer / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 1133-1136, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-244676
ABSTRACT
Epigenetic modifications, including DNA methylation, histone modifications, RNA epigenetics and nucleosome remodeling, are important for gene transcription, but such modifications do not change the coding sequence of the gene. Although these events are heritable, they are potentially reversible, thus opening up opportunities for the therapy of cancer. So epigenetic modifications have been thrusted into the forefront of new drug discoveries. Current knowledge suggests that the agents that intervene epigenetics by "turning back on" silenced genes may represent a significant advancement in treating many forms of cancer. In this review, we summarized the research progress of epigenetic gene regulation and the proteins which could read epigenetic codes. And the relationship between epigenetics and cancer was discussed comprehensively.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Terapéutica
/
Histonas
/
Regulación de la Expresión Génica
/
Metilación de ADN
/
Epigénesis Genética
/
Genética
/
Metabolismo
/
Neoplasias
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Biomedical Engineering
Año:
2009
Tipo del documento:
Artículo
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