Clinical study of patient-controlled epidural analgesia with tetracaine hydrochloride after pulmonary lobectomy / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal
;
(4): 54-58, 2003.
Artículo
en Inglés
| WPRIM
| ID: wpr-244866
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the efficacy and safety of tetracaine hydrochloride in patient-controlled epidural analgesia (PCEA) after pulmonary lobectomy.</p><p><b>METHODS</b>Forty-three patients scheduled for elective pulmonary lobectomy under general anesthesia were randomly allocated into either tetracaine group (22 patients) or ropivacaine group (21 patients). In the tetracaine group, 0.15% tetracaine was used for postoperative PCEA, while 0.3% ropivacaine was used in the ropivacaine group. The duration of postoperative analgesia was 48 h. The PCEA included a bolus of 6 ml with a lockout time of 1 h. Postoperative pain score was measured by visa analogue scale (VAS). Forced expired volume at the 1st second (FEV1.0), forced vital capacity (FVC), FEV1.0/FVC and peak expired flow (PEF) were measured preoperatively and daily after surgery. Hemodynamics were monitored and recorded before and after each administration of local anesthetics during the period of the study.</p><p><b>RESULTS</b>VAS scores in both groups decreased significantly after a bolus injection of local anesthetics. There was no significant difference between the two groups in VAS either before or after the administration of PCEA. On the 1st and 2nd days after the operation, pulmonary function was reduced in both groups. However, there were no significant differences between the percentage of the changes of FEV1.0, FEV1.0/FVC and PEF in the two groups. There were also significant differences between the percentage of the changes of heart rate, mean arterial blood pressure and SpO2 after administration of local anesthetics. There was no significant difference in overall satisfaction with pain relief.</p><p><b>CONCLUSIONS</b>The analgesic effect of 0.15% tetracaine is similar to that of 0.3% ropivacaine used in patient-controlled epidural analgesia after thoracotomy. No serious side effects were observed.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Dolor Postoperatorio
/
Neumonectomía
/
Tetracaína
/
Dimensión del Dolor
/
Analgesia Epidural
/
Analgesia Controlada por el Paciente
/
Usos Terapéuticos
/
Quimioterapia
/
Amidas
/
Anestésicos Locales
Límite:
Adolescente
/
Adulto
/
Humanos
Idioma:
Inglés
Revista:
Chinese Medical Sciences Journal
Año:
2003
Tipo del documento:
Artículo
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