Research progress on molecular pathogenesis of myeloproliferative neoplasms / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 239-243, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-244946
ABSTRACT
Classical BCR/ABL fusion gene negative myeloproliferative neoplasms (MPN), including polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF), are clonal hematopoietic malignancies sharing in common origin in a multipotential hematopoietic stem cell. The phenotypic variability of the three entities can not be elucidated by JAK2V617F mutation only. Recent discoveries indicated that JAK2V617F allele burden, other mutated genes (such as TET2, ASXL1) and inherited predisposition can play roles in the complicated pathogenesis of MPN, which are summarized in this review.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Policitemia Vera
/
Neoplasias de la Médula Ósea
/
Predisposición Genética a la Enfermedad
/
Janus Quinasa 2
/
Mielofibrosis Primaria
/
Genética
/
Trombocitemia Esencial
/
Mutación
/
Trastornos Mieloproliferativos
Tipo de estudio:
Estudio de etiología
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Experimental Hematology
Año:
2011
Tipo del documento:
Artículo
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