Design, synthesis and biological evaluation of fingolimod analogues containing diphenyl ether moiety / 药学学报
Acta Pharmaceutica Sinica
;
(12): 896-904, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-244997
ABSTRACT
A novel series of fingolimod analogues containing diphenyl ether moiety were designed and synthesized based on the modification of immunosuppressive agent fingolimod used in the treatment of multiple sclerosis. Compounds were evaluated in vivo for lymphopenic activity and heart rate affection. Most compounds showed moderate lymphopenic activity. It is worth noting that compounds 6c, 6d and 14c-14e showed considerable immunosuppressive activities comparable to fingolimod. And compound 14e had no effect on heart rate.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Farmacología
/
Éteres Fenílicos
/
Relación Estructura-Actividad
/
Química
/
Clorhidrato de Fingolimod
/
Frecuencia Cardíaca
/
Inmunosupresores
/
Linfopenia
Límite:
Animales
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2014
Tipo del documento:
Artículo
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