The impurity profiling of simvastatin and its tablets by UPLC-MS/MS / 药学学报
Acta Pharmaceutica Sinica
;
(12): 672-678, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-245028
ABSTRACT
Investigation of simvastatin and its related substances was carried out using a reversed phase ultra performance liquid chromatography/tandem mass spectrometry method. The identification of impurities in simvastatin was performed with a triple-quadrupole mass spectrometer, with an electrospray ionization (ESI) source in the negative/positive ion mode. A total of 12 compounds were characterized in commercial samples, among which 2 impurities had never been reported. All the impurities were deduced based on the MS fragment pathways of simvastatin and the biosynthetic pathway of lovastatin. This work provides very useful information for quality control of simvastatin.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Control de Calidad
/
Comprimidos
/
Química
/
Contaminación de Medicamentos
/
Cromatografía Líquida de Alta Presión
/
Simvastatina
/
Espectrometría de Masa por Ionización de Electrospray
/
Espectrometría de Masas en Tándem
/
Cromatografía de Fase Inversa
/
Hipolipemiantes
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2014
Tipo del documento:
Artículo
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