Synthesis and in vitro cytotoxic activities of sorafenib derivatives / 药学学报
Acta Pharmaceutica Sinica
; (12): 639-643, 2014.
Article
en Zh
| WPRIM
| ID: wpr-245034
Biblioteca responsable:
WPRO
ABSTRACT
A series of novel sorafenib analogues were designed and synthesized. The cytotoxic activities of these compounds were tested in four tumor cell lines. Some of the compounds showed potent antiproliferative activity against the tested cell lines with IC50 = 4-20 micromol x L(-1). Some compounds demonstrated competitive antiproliferative activities to sorafenib against tested cancer cell lines. Among them, compound 7c demonstrated significant inhibitory activities on ACHN, HCT116 and MDA-MB-231 cell lines with IC50 values of 9.01, 4.97, 6.61 micromol x L(-1), respectively.
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Farmacología
/
Compuestos de Fenilurea
/
Relación Estructura-Actividad
/
Estructura Molecular
/
Química
/
Niacinamida
/
Concentración 50 Inhibidora
/
Línea Celular Tumoral
/
Proliferación Celular
/
Antineoplásicos
Límite:
Humans
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Año:
2014
Tipo del documento:
Article