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Advances in the application of gene therapy for Parkinson's disease with adeno-associated virus / 药学学报
Acta Pharmaceutica Sinica ; (12): 576-581, 2014.
Artículo en Chino | WPRIM | ID: wpr-245044
ABSTRACT
Vectors used to carry foreign genes play an important role in gene therapy, among which, the adeno-associated virus (AAV) has many advantages, such as nonpathogenicity, low immunogenicity, stable and long-term expression and multiple-tissue-type infection, etc. These advantages have made AAV one of the most potential vectors in gene therapy, and widely used in many clinical researches, for example, Parkinson's disease. This paper introduces the biological characteristics of AAV and the latest research progress of AAV carrying neurotrophic factor, dopamine synthesis related enzymes and glutamic acid decarboxylase gene in the gene therapy of Parkinson's disease.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Enfermedad de Parkinson / Descarboxilasas de Aminoácido-L-Aromático / Terapéutica / Terapia Genética / Técnicas de Transferencia de Gen / Dependovirus / Factor Neurotrófico Derivado de la Línea Celular Glial / Neurturina / Vectores Genéticos / Genética Límite: Animales / Humanos Idioma: Chino Revista: Acta Pharmaceutica Sinica Año: 2014 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Enfermedad de Parkinson / Descarboxilasas de Aminoácido-L-Aromático / Terapéutica / Terapia Genética / Técnicas de Transferencia de Gen / Dependovirus / Factor Neurotrófico Derivado de la Línea Celular Glial / Neurturina / Vectores Genéticos / Genética Límite: Animales / Humanos Idioma: Chino Revista: Acta Pharmaceutica Sinica Año: 2014 Tipo del documento: Artículo