Design, synthesis and antidiabetic activity of novel tetrahydrocarboline PPAR regulators / 药学学报
Acta Pharmaceutica Sinica
;
(12): 490-496, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-245057
ABSTRACT
A series of novel tetrahydrocarboline derivatives was designed and synthesized in order to discover more potent peroxisome proliferator-activated receptor (PPAR) alpha/gamma dual regulators. The structures of these compounds were confirmed by 1H NMR and HR-MS; their PPAR-regulating activities were evaluated in vitro. Compounds 6h, 6n, 6p and 6q exhibited more potent PPARalpha agonistic activities than the control drug WY14643, while compounds 60, 6g, 6i and 6q exhibited more potent PPARgamma agonistic activities than the control drug rosiglitazone. Compound 6q was discovered as a potent PPARalpha/gamma dual agonist and deserves further investigation.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Pirimidinas
/
Relación Estructura-Actividad
/
Carbolinas
/
Transfección
/
Diseño de Fármacos
/
Estructura Molecular
/
Células Cultivadas
/
Química
/
Tiazolidinedionas
Límite:
Animales
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2014
Tipo del documento:
Artículo
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