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A linkage disequilibrium study of methylenetetrahydrofolate reductase C677T and schizophrenia / 中华医学遗传学杂志
Chinese Journal of Medical Genetics ; (6): 198-200, 2002.
Artículo en Chino | WPRIM | ID: wpr-245334
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between the methylenetetrahy drofolate reductase (MTHFR) C677T missense mutation and schizophrenia by linkage disequilibrium study.</p><p><b>METHODS</b>Linkage disequilibrium analys is was conducted bet ween MTHFR C677T and schizophrenia in 115 affected-sib-pair (105) and trios (10) families by XDT and MAPMAKER/SIBS soft system. The analyses were performed in different diagnostic categories and combined with the age of onset as well.</p><p><b>RESULTS</b>No positive results were found in the analysis in all the family in all the four diagnostic categories. Significant P values, which were P<0.05, P<0.01 respectively, were observed in the families with the affected individual's onset age less than 25 years in all the four diagnostic categories.</p><p><b>CONCLUSION</b>The missense mutation of MTHFR C677T or other gene structure around this mutation may be one of the susceptibility gene of schizophrenia.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Esquizofrenia / ADN / Núcleo Familiar / Desequilibrio de Ligamiento / Salud de la Familia / Mutación Missense / Metilenotetrahidrofolato Reductasa (NADPH2) / Oxidorreductasas actuantes sobre Donantes de Grupo CH-NH / Frecuencia de los Genes / Genética Límite: Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Medical Genetics Año: 2002 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Esquizofrenia / ADN / Núcleo Familiar / Desequilibrio de Ligamiento / Salud de la Familia / Mutación Missense / Metilenotetrahidrofolato Reductasa (NADPH2) / Oxidorreductasas actuantes sobre Donantes de Grupo CH-NH / Frecuencia de los Genes / Genética Límite: Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Medical Genetics Año: 2002 Tipo del documento: Artículo