Analyses of genetic model of psoriasis vulgaris / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 108-111, 2002.
Artículo
en Chino
| WPRIM
| ID: wpr-245353
ABSTRACT
<p><b>OBJECTIVE</b>To explore the possible genetic model of psoriasis vulgaris.</p><p><b>METHODS</b>The complex segregation analysis and heritability calculation were performed with the aid of Penrose method, Falconer regression method and SAGE-REGTL program.</p><p><b>RESULTS</b>It was found that in 1043 patients with psoriasis vulgaris, 305 patients (29.24%) have the family history of psoriasis, and 738 patients have not the family history. A ratio of s/q approached 1/(square root of q) with Penrose method, and the heritability values of psoriasis in the first-degree and second-degree relatives were 67.04%, 46.6% respectively. By complex segregation analysis, Mendelian, non-major-gene model and environment model were rejected for psoriasis.</p><p><b>CONCLUSION</b>The results suggest that psoriasis follows a pattern of polygenetic or multifactorial inheritance rather than single-gene inheritance.</p>
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Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Psoriasis
/
Salud de la Familia
/
Interpretación Estadística de Datos
/
Genética
/
Modelos Genéticos
Límite:
Adolescente
/
Adulto
/
Anciano
/
Niño
/
Child, preschool
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Medical Genetics
Año:
2002
Tipo del documento:
Artículo
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