Comparative study of HLA-DQA1 and HLA-DRB1 allele in patients with endometriosis and adenomyosis / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 49-51, 2002.
Article
en Zh
| WPRIM
| ID: wpr-245366
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To make a comparative study of HLA-DQA1 and HLA-DRB1 allele frequencies in the cases of endometriosis and adeonmyosis.</p><p><b>METHODS</b>The allelic types of HLA-DQA1 and HLA-DRB1 were detected by polymerase chain reaction-sequence specific primers (PCR-SSP) technique in 51 cases of endometriosis, 45 cases of adenomyosis, and 44 normal individuals as the control.</p><p><b>RESULTS</b>The frequencies of HLA-DQA1*0401(7.8%, 10.0%) were significantly increased in the endometriosis group and the adenomyosis group (Pc=0.03, Pc=0.01), and the frequencies of HLA-DQA1*0301(8.8%, 5.6%) were significantly decreased in these two groups (Pc=0.00, Pc=0.00).There was no significant difference between the frequencies of HLA-DQA1 and HLA-DRB1 of endometriosis and adenomyosis.</p><p><b>CONCLUSION</b>The results indicate that HLA-DQA1*0301 and *0401 alleles are associated with both endometriosis and adenomyosis, and there is perhaps common mechanism involved in both endometriosis and adenomyosis based on HLA-DQA1 and HLA-DRB1 allele frequencies.</p>
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Índice:
WPRIM
Asunto principal:
Antígenos HLA-DQ
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Antígenos HLA-DR
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Reacción en Cadena de la Polimerasa
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Predisposición Genética a la Enfermedad
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Pueblo Asiatico
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Endometriosis
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Cadenas alfa de HLA-DQ
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Cadenas HLA-DRB1
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Frecuencia de los Genes
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Genética
Límite:
Female
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Humans
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Año:
2002
Tipo del documento:
Article