Linkage analysis of X-linked nuclear protein gene in Smith-Fineman-Myers syndrome / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 22-25, 2002.
Artículo
en Chino
| WPRIM
| ID: wpr-245373
ABSTRACT
<p><b>OBJECTIVE</b>To determine the linkage between Smith-Fineman-Myers syndrome (SFMS) and X-linked nuclear protein(XNP) locus.</p><p><b>METHODS</b>Polymerase chain reaction and denaturing polyacrylamide gel electrophoresis were used to genotype two polymorphic short tandem repeats within XNP gene.</p><p><b>RESULTS</b>One of the two short tandem repeats was informative in SFMS family from Shandong, China. Recombination between SFMS locus and XNP gene was observed in the SFMS family.</p><p><b>CONCLUSION</b>XNP gene is not associated with the disease in the SFMS family from Shandong, China. SFMS exhibits locus heterogeneity at molecular level.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Linaje
/
Fenotipo
/
Polimorfismo Genético
/
Recombinación Genética
/
Síndrome
/
Cromosoma X
/
Anomalías Múltiples
/
Proteínas Nucleares
/
ADN Helicasas
/
Anomalías Craneofaciales
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Medical Genetics
Año:
2002
Tipo del documento:
Artículo
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