Expression of proline-rich tyrosine kinase-2 in human primary colorectal carcinoma and its prognostic implication / 中华外科杂志
Chinese Journal of Surgery
;
(12): 440-442, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-245560
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of proline-rich tyrosine kinase-2 (Pyk2) in human primary colorectal carcinoma (CRC) and it's prognostic significance.</p><p><b>METHODS</b>The expression of Pyk2 was retrospectively examined with immunohistochemistry (IHC) in 108 tissues of primary CRC. The correlation of Pyk2 expression to prognosis and relevant clinical factors were analyzed.</p><p><b>RESULTS</b>The rate of Pyk2 low-expression in CRC was 56.5% (61/108). The expression of Pyk2 correlated significantly to the histological grade (P < 0.05) and the TNM stage (P < 0.05), while no correlation between Pyk2 expression and age, tumor size (P > 0.05). Patients with Pyk2 over-expression had significantly higher 5-year survival rate (66.0%) than those with Pyk2 low-expression (31.4%). Pyk2 expression, together with carcinoma histologic grade and TNM stage were prognostic factors to CRC on the multivariate analysis.</p><p><b>CONCLUSIONS</b>Pyk2 expression can be a prognostic factor to the CRC patients together with other predictors.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Pronóstico
/
Neoplasias Colorrectales
/
Quinasa 2 de Adhesión Focal
/
Metabolismo
Tipo de estudio:
Estudio pronóstico
Límite:
Adulto
/
Anciano
/
Aged80
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Surgery
Año:
2008
Tipo del documento:
Artículo
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