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Clinical trial on treatment of Parkinson's disease of Gan-Shen yin deficiency type by recipe for nourishing Gan-Shen / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine ; (12): 780-784, 2007.
Artículo en Chino | WPRIM | ID: wpr-245644
ABSTRACT
<p><b>OBJECTIVE</b>To observe the curative effect of the recipe for nourishing Gan-Shen on Parkinson's disease (PD) of Gan-Shen yin deficiency type.</p><p><b>METHODS</b>One hundred and twenty-one PD patients were ran-domly assigned by blocking design to the control group and the treated group in the ratio of 11. All were treated according to the international medication guiding principle for PD treatment, but the treated group was ad-ministered with the recipe for nourishing Gan-Shen additionally. The treatment course lasted for 12 consecutive months, and the end point was the end of the 12th month. The unified Parkinson's disease rating scale (UP-DRS) score, TCM primary and secondary symptom scores were evaluated before treatment, every 3 months of treatment and at the end point. The average daily levodopa dose and the Hoehn & Yahr grading were assessed before treatment and at the end point.</p><p><b>RESULTS</b>After treatment, UPDRS score in both groups showed an ascending trend at a slower rate in the treated groups than in the control group. At the 9th and 12th month of medication, a significant difference was found in UPDRS score between the two groups (P < 0.05), and the TCM symptom score was obviously lower in the treated group than in the control group (P < 0.05). At the end point of the trial, the average daily levodopa dose used was lower in the treated group than in the control group (P < 0.05) and there was no significant difference in the Hoehn & Yahr score between the two groups (P > 0.05).</p><p><b>CONCLUSION</b>The recipe for norishing Gan-Shen can slow the ascending trend of UPDRS score in the PD patients, improve the symptoms of Gan-Shen yin deficiency, and decrease the daily levodopa dose used, showing a curative effect on PD of Gan-Shen yin deficiency type.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Enfermedad de Parkinson / Medicamentos Herbarios Chinos / Levodopa / Deficiencia Yin / Resultado del Tratamiento / Usos Terapéuticos / Diagnóstico / Diagnóstico Diferencial / Quimioterapia / Quimioterapia Combinada Tipo de estudio: Ensayo Clínico Controlado / Estudio diagnóstico Límite: Anciano / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Integrated Traditional and Western Medicine Año: 2007 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Enfermedad de Parkinson / Medicamentos Herbarios Chinos / Levodopa / Deficiencia Yin / Resultado del Tratamiento / Usos Terapéuticos / Diagnóstico / Diagnóstico Diferencial / Quimioterapia / Quimioterapia Combinada Tipo de estudio: Ensayo Clínico Controlado / Estudio diagnóstico Límite: Anciano / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Integrated Traditional and Western Medicine Año: 2007 Tipo del documento: Artículo