Optimization of formulation matrix proportion and preparation technology of realgar floating tablets for gastric retention by uniform design and correlation analysis / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 391-393, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-245970
ABSTRACT
<p><b>OBJECTIVE</b>To optimize the different components proportions of the Realgar floating tablets for gastric retention by uniform design and correlation analysis.</p><p><b>METHOD</b>With the different dosage of hydroxypropyl methyl cellulose (HPMC) as the tablets frame matrix, uniform design and correlation analysis were used to optimize the best component proportions of formula, and to measure the dissolution of the tablets in vitro.</p><p><b>RESULT</b>Dissolution of the tablets in vitro was conformed to the expectation of experiment. The drug-release mechanism was by diffusion and corrosion at the same time.</p><p><b>CONCLUSION</b>The Realgar floating tablets for gastric retention achieved the goal of design, which demand sustained release and safety.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Arsenicales
/
Solubilidad
/
Estómago
/
Sulfuros
/
Comprimidos
/
Materia Medica
/
Farmacocinética
/
Química
/
Administración Oral
/
Povidona
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2007
Tipo del documento:
Artículo
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