Astragalus membranaceus promote expression of insulin-like growth factor 1 in rat model of olivo-cerebellar degeneration / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 242-245, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-245999
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of Astragalus membranaceus (AM) on insulin-like growth factor 1 (IGF-1) expression in a rat model of olivo-cerebellar degeneration and assess the neuroprotective actions of AM meanwhile.</p><p><b>METHOD</b>Rats model of olivo-cerebellar degeneration was established by using 3-acetylpyridine. The effect of AM on the expression of Calbindin D-28K in inferior olive (IO) neurons by immunohistochemistry, the serum IGF-1 level by Elisa, the IGF-1 mRNA level in the cerebellum by RT-PCR were detected respectively.</p><p><b>RESULT</b>AM effectively improve the serum IGF-1 level, Cerebellar IGF-1 mRNA level and the survival of the 10 neurons in a rat model of olivo-cerebellar degeneration, even at a lower dose (9 g x kg(-1)), and the effect was in a dose-dependent manner.</p><p><b>CONCLUSION</b>AM could effectively upregulate the IGF-1 expression in the rat model of olivo-cerebellar degeneration, and have neuroprotective effect on IO neurons.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Plantas Medicinales
/
Piridinas
/
Sangre
/
Proteína G de Unión al Calcio S100
/
ARN Mensajero
/
Factor I del Crecimiento Similar a la Insulina
/
Ensayo de Inmunoadsorción Enzimática
/
Núcleo Olivar
/
Medicamentos Herbarios Chinos
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2007
Tipo del documento:
Artículo
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