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Astragalus membranaceus promote expression of insulin-like growth factor 1 in rat model of olivo-cerebellar degeneration / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 242-245, 2007.
Artículo en Chino | WPRIM | ID: wpr-245999
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of Astragalus membranaceus (AM) on insulin-like growth factor 1 (IGF-1) expression in a rat model of olivo-cerebellar degeneration and assess the neuroprotective actions of AM meanwhile.</p><p><b>METHOD</b>Rats model of olivo-cerebellar degeneration was established by using 3-acetylpyridine. The effect of AM on the expression of Calbindin D-28K in inferior olive (IO) neurons by immunohistochemistry, the serum IGF-1 level by Elisa, the IGF-1 mRNA level in the cerebellum by RT-PCR were detected respectively.</p><p><b>RESULT</b>AM effectively improve the serum IGF-1 level, Cerebellar IGF-1 mRNA level and the survival of the 10 neurons in a rat model of olivo-cerebellar degeneration, even at a lower dose (9 g x kg(-1)), and the effect was in a dose-dependent manner.</p><p><b>CONCLUSION</b>AM could effectively upregulate the IGF-1 expression in the rat model of olivo-cerebellar degeneration, and have neuroprotective effect on IO neurons.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Plantas Medicinales / Piridinas / Sangre / Proteína G de Unión al Calcio S100 / ARN Mensajero / Factor I del Crecimiento Similar a la Insulina / Ensayo de Inmunoadsorción Enzimática / Núcleo Olivar / Medicamentos Herbarios Chinos Tipo de estudio: Estudio pronóstico Límite: Animales Idioma: Chino Revista: China Journal of Chinese Materia Medica Año: 2007 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Plantas Medicinales / Piridinas / Sangre / Proteína G de Unión al Calcio S100 / ARN Mensajero / Factor I del Crecimiento Similar a la Insulina / Ensayo de Inmunoadsorción Enzimática / Núcleo Olivar / Medicamentos Herbarios Chinos Tipo de estudio: Estudio pronóstico Límite: Animales Idioma: Chino Revista: China Journal of Chinese Materia Medica Año: 2007 Tipo del documento: Artículo