Study on effect of pH on rectum permeability of active ingredients in Reduning suppositories in vitro / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1493-1496, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-246071
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of different pH on rectum permeability of chlorogenic acid and geniposide.</p><p><b>METHOD</b>Four kinds of Reduning suppositories of different pH were separated and put into the rectum to study the suppositories in vitro and the content of chlorogenic acid and geniposide samples was determined by HPLC to calculate the permeation in 24 hours.</p><p><b>RESULT</b>With increase of pH within 2.5-7.4, the steady state flux of chlorogenic acid was increased, but the steady state flux of geniposidesamples was steady.</p><p><b>CONCLUSION</b>Adjusted the pH can increase the rectum permeability of active ingredients in Reduning auppositories.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Permeabilidad
/
Recto
/
Supositorios
/
Medicamentos Herbarios Chinos
/
Farmacocinética
/
Ácido Clorogénico
/
Ratas Sprague-Dawley
/
Iridoides
/
Concentración de Iones de Hidrógeno
/
Metabolismo
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2015
Tipo del documento:
Artículo
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