Alterations of NK cell frequency and function in HIV/HCV co-infected patients / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 248-250, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-246254
ABSTRACT
<p><b>OBJECTIVE</b>To study the impacts of HIV/HCV co-infection to NK cells by investigating the changes of frequencies and functions of NK cells in HIV/HCV co-infected patients.</p><p><b>METHODS</b>Frequencies and counts of NK cells were measured in patients with HIV mono-infection, HCV monoinfection, HIV/HCV co-infection and health control (HC) group by flow cytometer (FCM). After stimulated with PMA and K562 cells, PBMCs were examined the proportion of IFN-gamma+ NK cells by FCM. Proportion of killed K562 cells were detected to analyze the killing functions of NK cells.</p><p><b>RESULTS</b>The frequencies of NK cells, the percentages of IFN-gamma+ NK cells as well as the functions of NK cells killing the K562 cells in HIV/HCV co-infection, HIV mono-infection and HCV mono-infection groups were all lower than those of HC group significantly, the absolute counts and killing functions of NK cells in co-infection group were significantly lower than those of HIV or HCV mono-infection group.</p><p><b>CONCLUSIONS</b>The counts and functions of NK cells were affected more in HIV/HCV co-infections than those in HIV or HCV mono-infection.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Células Asesinas Naturales
/
Estudios de Casos y Controles
/
Infecciones por VIH
/
Recuento de Células
/
Hepatitis C
/
Células K562
/
Biología Celular
/
Alergia e Inmunología
/
Coinfección
/
Citometría de Flujo
Tipo de estudio:
Estudio observacional
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Experimental and Clinical Virology
Año:
2011
Tipo del documento:
Artículo
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