Oligodendrocyte and spinal cord injury / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 1226-1229, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-246475
ABSTRACT
Spinal cord injury (SCI) is frequently companied by necrosis and apoptosis of oligodendrocytes (OLs), which contributes to demyelination of myelinated nerve fibers and their electrophysiological defects. This pathological demyelination often results in sensory or motor deficits. Here, we first focus on the microenvironment changes after SCI that cause OLs' death, then discuss the major mechanism of endogenous oligodendrocytogenesis and axonal remyelination, and finally summarize current therapies targeting OLs protection and replacement.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Fisiología
/
Médula Espinal
/
Traumatismos de la Médula Espinal
/
Terapéutica
/
Oligodendroglía
/
Muerte Celular
/
Apoptosis
/
Necrosis
/
Fibras Nerviosas Mielínicas
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Journal of Biomedical Engineering
Año:
2012
Tipo del documento:
Artículo
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