Estrogen receptors gene polymorphisms in patients with chronic periodontitis / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 139-144, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-246637
ABSTRACT
<p><b>OBJECTIVE</b>To determine whether polymorphisms in the estrogen receptor (ER) genes are associated with chronic periodontitis in a Chinese population overall the Shanxi territory.</p><p><b>METHODS</b>109 patients with chronic periodontitis and 99 healthy controls were recmited in this study. Genomic DNA was extracted from oral mucosa swab sample of each subject by the Chelex-100 method. Determination of the ER-alpha and -beta polymorphisms was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), respectively.</p><p><b>RESULTS</b>The analysis of the Xba I polymorphisms in ER-alpha gene revealed significant differences between patients and controls. The detection frequency of XX genotype was significantly higher in the chronic periodontitis patients than in control subjects. The difference between the female chronic periodontitis patients and healthy controls was statistically significant, but no difference was found between the male patients and controls. Nevertheless, no significant association was noted in the frequency of both Rsa I and Alu I polymorphisms in ER-beta gene between chronic periodontitis and controls.</p><p><b>CONCLUSION</b>It is indicated that the ER-alpha XX genotype may be a susceptible indicator for chronic periodontitis in female Han Chinese subjects.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Polimorfismo Genético
/
Polimorfismo de Longitud del Fragmento de Restricción
/
Estudios de Casos y Controles
/
Reacción en Cadena de la Polimerasa
/
Predisposición Genética a la Enfermedad
/
Pueblo Asiatico
/
Receptor alfa de Estrógeno
/
Periodontitis Crónica
/
Frecuencia de los Genes
/
Genotipo
Tipo de estudio:
Estudio observacional
/
Factores de riesgo
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
West China Journal of Stomatology
Año:
2010
Tipo del documento:
Artículo
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