Development of Regulatory T Cells Mediated by NF-κB and Its Role in GVHD -Review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1280-1283, 2016.
Artículo
en Chino
| WPRIM
| ID: wpr-246775
ABSTRACT
Graft versus host disease (GVHD) is the major complication of allogenic hematopoietic stem cell transplantation (allo-HSCT), and is a mainly responsible result for the non-recurrence-related mortality of long-term survived patient after transplantation. Studies indicated that regulatory T (Treg) cells can inhibit early-GVHD. Since the transcriptional factor NF-κB has been implicated in the regulation of Treg cell proliferation and activation, it becomes a potential target of GVHD therapy. Thus, in this review the function and signaling pathway of NF-κB, as well as the relationship between GVHD and NF-κB, are discussed and summarized.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
FN-kappa B
/
Linfocitos T Reguladores
/
Trasplante de Células Madre Hematopoyéticas
/
Enfermedad Injerto contra Huésped
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Experimental Hematology
Año:
2016
Tipo del documento:
Artículo
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