The therapeutic effect of propranolol with 1064 nm Nd: YAG laser on proliferating hemangioma in body surface / 中华整形外科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To observe the therapeutic effect of propranolol with 1 064 nm NdYAG laser on proliferating hemangioma in body surface.</p><p><b>METHODS</b>97 patients with proliferating hemangiomas in body surface were randomly assigned to three groups A group (32 patients were treated by propranolol with 1064 nm NdYAG laser), B group (35 patients were treated by 1064 nm NdYAG laser), C group (30 patients were treated by propranolol). Their visual analog scores, clinical outcomes and adverse events were compared respectively.</p><p><b>RESULTS</b>18 weeks later, A group had a mean visual analog score of 65.50 +/- 16.55, compared with 54.03 +/- 20.13 in B group, 28.08 +/- 30.34 in C group (P < 0.05); 24 weeks later, the mean visual analog scores of three groups were 76.88 +/- 19.05, 63.89 +/- 19.43 and 45.48 +/- 31.86 (P < 0.05). After 24 weeks' treatment, 9 cases (28.1%) in A group, 3 cases (8.6%) in B group, 1 cases (4.0%) in C group obtained complete healing (P < 0.05). To effect of adverse events in body surface, the mean score of B group was higher than the scores of A group and C group (P < 0.05).</p><p><b>CONCLUSIONS</b>Propranolol with 1064 nm NdYAG laser is effective and safe in the treatment of proliferating hemangioma.</p>