Relaxin inhibit cardiac fibrosis induced by phorbol 12-myristate 13-acetate / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 138-141, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-247071
ABSTRACT
Relaxin is known to inhibit cardiac fibrosis. However, it is unclear whether relaxin could regulate the effects of Phorbol 12-myristate 13-acetate (PMA, PKC activator) on cardiac fibrosis. So the influence of relaxin on the cell proliferation and collagen expression induced by PMA in cultured cardiac fibroblasts was studied. It showed that PMA significantly increased cardiac fibroblasts proliferation, Type I pro-collagen protein expression, Type I pro-collagen mRNA expression, and rhRLX absolutely significantly decreased PMA induced effects on cardiac fibroblasts proliferation and Type I pro-collagen expressions, indicating that relaxin could inhibit cardiac fibrosis induced by PMA.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Relaxina
/
Fibrosis
/
Acetato de Tetradecanoilforbol
/
Células Cultivadas
/
Ratas Sprague-Dawley
/
Usos Terapéuticos
/
Fibroblastos
/
Cardiopatías
/
Animales Recién Nacidos
Límite:
Animales
Idioma:
Inglés
Revista:
Biomedical and Environmental Sciences
Año:
2014
Tipo del documento:
Artículo
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