Relaxin inhibit cardiac fibrosis induced by phorbol 12-myristate 13-acetate / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 138-141, 2014.
Article
en En
| WPRIM
| ID: wpr-247071
Biblioteca responsable:
WPRO
ABSTRACT
Relaxin is known to inhibit cardiac fibrosis. However, it is unclear whether relaxin could regulate the effects of Phorbol 12-myristate 13-acetate (PMA, PKC activator) on cardiac fibrosis. So the influence of relaxin on the cell proliferation and collagen expression induced by PMA in cultured cardiac fibroblasts was studied. It showed that PMA significantly increased cardiac fibroblasts proliferation, Type I pro-collagen protein expression, Type I pro-collagen mRNA expression, and rhRLX absolutely significantly decreased PMA induced effects on cardiac fibroblasts proliferation and Type I pro-collagen expressions, indicating that relaxin could inhibit cardiac fibrosis induced by PMA.
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1
Índice:
WPRIM
Asunto principal:
Patología
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Relaxina
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Fibrosis
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Acetato de Tetradecanoilforbol
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Células Cultivadas
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Ratas Sprague-Dawley
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Usos Terapéuticos
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Fibroblastos
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Cardiopatías
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Animales Recién Nacidos
Límite:
Animals
Idioma:
En
Revista:
Biomedical and Environmental Sciences
Año:
2014
Tipo del documento:
Article