Preparation of rat model of systemic inflammatory response syndrome induced by zymosan / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 641-646, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-247200
ABSTRACT
<p><b>OBJECTIVE</b>To establish a model of systemic inflammatory response syndrome (SIRS) in rats.</p><p><b>METHODS</b>SD rats were intraperitoneally injected with different concentrations of zymosan suspension. The general status, temperature, white cell count, tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), interleukin-10 (IL-10) and the pathological changes of main organs were examined.</p><p><b>RESULTS</b>The conditions of rats receiving zymosan doses of 750 mg/kg and 1000 mg/kg were consistent with the criteria of SIRS model; however, the mortality of 1000 mg/kg group was higher than that of 750 mg/kg group.</p><p><b>CONCLUSION</b>The rat model of systemic inflammatory response syndrome has been successfully induced.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Parafina
/
Patología
/
Zimosan
/
Sangre
/
Vísceras
/
Interleucina-6
/
Factor de Necrosis Tumoral alfa
/
Interleucina-10
/
Ratas Sprague-Dawley
/
Síndrome de Respuesta Inflamatoria Sistémica
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Chino
Revista:
Journal of Zhejiang University. Medical sciences
Año:
2011
Tipo del documento:
Artículo
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