Anti-proliferation and chemo-sensitization effects of apigenin on human lung cancer cells / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 508-514, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-247222
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the antitumor effect of apigenin on human lung cancer cells.</p><p><b>METHODS</b>The anti-proliferation and sensitization effects of apigenin on human lung cancer cells was accessed by counting cells after Trypan blue staining and MTS assay.</p><p><b>RESULTS</b>(1) Apigenin significantly suppressed the proliferation of four types of human lung cancer cells (A549P=0.041, H460P=0.050, LTEP-a2P=0.039, H292P=0.016); (2) Apigenin significantly increased the susceptibility of human lung cancer cells to antitumor drugs (P<0.05 or P<0.01) in a synergistic way (almost all of the combination index values are less than 1).</p><p><b>CONCLUSION</b>Apigenin widely inhibits cell proliferation of various lung cancer cell lines in a dose-dependent manner and the combination treatment of apigenin and antitumor drugs is very effective in human lung cancer cells, and Nrf2-ARE pathway may contribute to the mechanism.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Farmacología
/
Línea Celular Tumoral
/
Apigenina
/
Proliferación Celular
/
Sinergismo Farmacológico
/
Neoplasias Pulmonares
/
Antineoplásicos
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Zhejiang University. Medical sciences
Año:
2011
Tipo del documento:
Artículo
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