Components of myrsinane-type diterpenes from Euphorbia prolifera / 浙江大学学报·医学版

ABSTRACT

<p><b>OBJECTIVE</b>To extract and isolate the component from myrsinane-type diterpenes of Euphorbia prolifera.</p><p><b>METHODS</b>Petroleum extraction and chromatography on the silica gel were used to extract and isolate the diterpenes of Euphorbia prolifera.</p><p><b>RESULTS</b>Eight components of myrsinol diterpenes were isolated, namely Proliferin A(1), Proliferin B (2), Proliferin C(3), Proliferin D(4), Euphorprolitherin B(5), Euphorprolitherin D(6), SPr5(7) and 14-desoxo-3-O-prorionyl-5, 15-di-O-acetyl-7-O-nicotinoyl-myrsinol-14β-acetate(8). Their structures were identified with mass-spectroscopic methods and NMR techniques. The cytotoxicity of compounds 1, 2, and 4 against cancer cells was evaluated, with compound 1 being active against A2780 cancer cells (IC(50) 7.7 μmol/L).</p><p><b>CONCLUSION</b>Myrsinane-type diterpene Proliferin A from Euphorbia prolifera shows cytotoxic effect against human ovarian cancer cell line A2780.</p>