Efficacy of bismuth-based quadruple therapy as first-line treatment for Helicobacter pylori infection / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 327-331, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-247253
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy of bismuth-based quadruple therapy as the first-line treatment for H.pylori infection.</p><p><b>METHODS</b>A total of 136 patients with H.pylori related peptic ulcer or chronic gastritis were randomized into two groups 67 patients in bismuth-based quadruple group received esomeprazole 20 mg, clarithromycin 0.5 g,amoxicillin 1.0 g,and bismuth potassium citrate 220 mg for 7 d; 69 patients in standard triple group received esomeprazole 20 mg, clarithromycin 0.5 g and amoxicillin 1.0 g for 7 d. Outcome of eradication therapy was assessed by (14)C-UBT. On ITT and PP analysis, calculating the cost-effectiveness ratio (C/E) and the incremental cost-effectiveness ratio (delta C/delta E).</p><p><b>RESULT</b>On ITT and PP analysis, the eradication rates of the quadruple therapy group were 82.09% and 88.71%, and those of the triple therapy group were 66.67% and 73.02% (P<0.05). The cost-effectiveness ratio of two groups was 4.15 and 4.82; The incremental cost-effectiveness ratio of quadruple therapy group was 1.02 as against triple therapy group.</p><p><b>CONCLUSION</b>Compared to the standard triple therapy regimen, the bismuth-containing quadruple therapy regimen has higher eradication rate and cost-effectiveness, which can be recommended as the fist-line treatment for H.pylori infection.</p>
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Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Bismuto
/
Estudios de Seguimiento
/
Infecciones por Helicobacter
/
Resultado del Tratamiento
/
Análisis Costo-Beneficio
/
Usos Terapéuticos
/
Quimioterapia
/
Quimioterapia Combinada
/
Economía
/
Antiulcerosos
Tipo de estudio:
Ensayo Clínico Controlado
/
Evaluación Económica en Salud
/
Estudio observacional
/
Estudio pronóstico
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Journal of Zhejiang University. Medical sciences
Año:
2011
Tipo del documento:
Artículo
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