Screening for the microdeletions of azoospermia factor on the Y chromosome in male infertile patients from Guangzhou / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 564-566, 2007.
Article
en Zh
| WPRIM
| ID: wpr-247268
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between microdeletion of azoospermia factor (AZF) and male infertility.</p><p><b>METHODS</b>Multiplex PCR was used to detect Y chromosome microdeletion in AZFa, AZFb and AZFc in 103 cases of idiopathic azoospermia, 72 cases of severe idiopathic oligozoospermia, and 60 healthy male controls.</p><p><b>RESULTS</b>No microdeletion was found in 60 controls. Y chromosome microdeletion was found in 19 of 175 azoospermia patients, the total prevalence rate of microdeletion was 10.9%. There were 15 cases (11 for azoospermia, 4 for severe oligozoospermia) in AZFc (8.6%), 3 cases (1 for azoospermia, 2 for severe oligozoospermia) in AZFb+c (1.7%), 1 case (azoospermia) in AZFa+b+c (0.6%). According to statistics, the difference of microdeletion rate between two groups was significant(P < 0.01).</p><p><b>CONCLUSION</b>Y chromosome microdeletions is an important reason of azoospermia. Screening of Y chromosome microdeletions for azoospermia patients before intracytoplasmic sperm injection treatment is essential.</p>
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Índice:
WPRIM
Asunto principal:
Oligospermia
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Estudios de Casos y Controles
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China
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Pruebas Genéticas
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Deleción Cromosómica
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Proteínas de Plasma Seminal
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Cromosomas Humanos Y
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Pueblo Asiatico
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Diagnóstico
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Azoospermia
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
Límite:
Adult
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Female
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Humans
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Male
País/Región como asunto:
Asia
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Año:
2007
Tipo del documento:
Article