Your browser doesn't support javascript.
loading
A study of paternity testing with considering mutation / 中华医学遗传学杂志
Chinese Journal of Medical Genetics ; (6): 417-421, 2007.
Artículo en Chino | WPRIM | ID: wpr-247304
ABSTRACT
<p><b>OBJECTIVE</b>To formulate recommendations in the evaluation of results of genetic analyses in paternity testing under considering mutations.</p><p><b>METHODS</b>A total of 15 short tandem repeat(STR) loci were employed for this study, which were included CSF1PO, FGA, TH01, TPOX, VWA, D3S1358, D5S818, D7S820, D8S1179, D13S317, D16S539, D18S51, D21S11, PentaD and PentaE. Both 100 cases of true trio and 100 cases of false trio were investigated.</p><p><b>RESULTS</b>The numbers of mismatch alleles in different STR loci were observed in 100 cases of false trio. The different distributions of paternity index were obtained, including the changes of paternity index in each case of true trio under simulated mutations.</p><p><b>CONCLUSION</b>In order to avoid the effect of mutations, the exclusion of paternity was never considered on the basis of a single locus. The threshold values of the combined probability of exclusion and the paternity index were important for both exclusion and inclusion of paternity. The scientific evidence for paternity testing can be obtained when both the combined probability of exclusion and the paternity index meet the threshold values. However, when either the combined probability of exclusion or the paternity index can not meet the threshold values, more genetic markers should be added.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Paternidad / Núcleo Familiar / Reproducibilidad de los Resultados / Repeticiones de Microsatélite / Genética Forense / Genética / Métodos / Mutación Límite: Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Medical Genetics Año: 2007 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Paternidad / Núcleo Familiar / Reproducibilidad de los Resultados / Repeticiones de Microsatélite / Genética Forense / Genética / Métodos / Mutación Límite: Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Medical Genetics Año: 2007 Tipo del documento: Artículo