Analysis of the mutation of BRCA1 gene in 70 Uigur women breast cancer patients in Xinjiang / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 341-344, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-247319
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the mutations of BRCA1 in breast cancer patients of Uigur women in Xinjiang.</p><p><b>METHODS</b>By using single strand conformation polymorphism (SSCP) and DNA sequencing, BRCA1 mutations were detected in 70 Uigur women breast cancer cases and 32 cases of benign breast diseases and non-tumor tissue next to carcinoma.</p><p><b>RESULTS</b>(1) 12 new loci of BRCA1 gene mutation were detected firstly in 70 Uigur women breast cancer patients. (2)The frequency of BRCA1 mutation in 70 Uigur women breast cancer cases was 12.86% (9/70). The frequency of BRCA1 mutation in Uigur women early onset breast cancer was 31.82% (7/22), which was significantly higher than that in late onset group (2/48, 4.16%) (chi(2) =10.295, P<0.01). (3) There were BRCA1 gene polymorphisms in 9 of 70 Uigur women breast cancer patients. The loci of polymorphisms in 8 of 9 cases were 3232A>G. (4)In the research group two cases of bilateral breast cancer were found with BRCA1 gene mutation.</p><p><b>CONCLUSION</b>The mutation of BRCA1 gene may be related to Uigur women breast cancer and bilateral breast cancer.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neoplasias de la Mama
/
Intrones
/
Etnicidad
/
China
/
Polimorfismo Conformacional Retorcido-Simple
/
Genes BRCA1
/
Pueblo Asiatico
/
Genética
/
Mutación
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
País/Región como asunto:
Asia
Idioma:
Chino
Revista:
Chinese Journal of Medical Genetics
Año:
2007
Tipo del documento:
Artículo
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